Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals.

These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents.

Discusses special considerations and emerging topics including pregnancy in transgender men, obesity and metabolism, and endocrine emergencieįor the past 40 years, metal-based drugs have been widely used for the treatment of cancer.

Explores from a clinical standpoint with practical applications useful for students, residents, fellows, mid-level providers, and practicing physicians.

Explains normal physiology of pregnancy in addition to the physiology, evaluation, and management of endocrine diseases in pregnancy and in the prepartum and postpartum periods.

This book serves as essential reading for Endocrinology fellows and Obstetrics and Gynecology residents. It provides readers with a detailed overview in a compact and easy-to-read format. Evaluation and management of endocrine disorders including, but not limited to, diabetes mellitus, thyroid disease, and various endocrine tumors are discussed. In addition, it serves as a relevant and synoptic resource for the clinical management of endocrine disorders in pregnancy and the prepartum and postpartum periods. This book delivers comprehensive explanations of normal hormonal physiology during pregnancy and descriptions of the hormonal pathology associated with various endocrine disease states.

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